MolNFT v1 · #81595 · protein
Structural basis of nuclear import of flap endonuclease 1 (FEN1)
3UVU · Flap endonuclease 1 (FEN1) peptide: “Structural basis of nuclear import of flap endonuclease 1 (FEN1)”. X-ray diffraction, 2 pockets (best druggability 0.46). MolNFT v1 #81595 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3UVU
- Type
- protein
- Length
- 444 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Flap endonuclease 1 (FEN1) peptide; Importin subunit alpha-2
- UniProt
- P39748, P52293
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Flap endonuclease 1 (FEN1) peptide | protein | 19 | 0% helix, 0% strand | P39748 |
| A | Importin subunit alpha-2 | protein | 425 | 72% helix, 0% strand | P52293 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.46 | 0.82 | 13 | empty |
| 2 | 76 | 0.43 | 0.81 | 16 | empty |
Interfaces
1 interface between chains.
- B–A · 1393 Ų buried · 36 hydrogen bonds · protein-protein
Compared structures
- 3UVU · Structural basis of nuclear import of Flap endonuclease 1 (FEN1) · the same entry in another collection · chain B against B, TM-score 1.00
- P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P39748 · AlphaFold monomer V2.0 prediction for flap endonuclease 1 (P39748) · a predicted model of the same protein · chain B against A, TM-score 0.20
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P39748
- Every structure of UniProt P52293
- Elsewhere: RCSB PDB 3UVU · PDBe 3UVU · UniProt P39748 · UniProt P52293
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