UniProt P39748
Flap endonuclease 1 (P39748)
Flap endonuclease 1 (UniProt P39748), EC 3.1.-.-: 27 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P39748
- Protein
- Flap endonuclease 1
- EC
- 3.1.-.-
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 22 · 4 records with a druggable one
Structures
28 records of P39748 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1U7B | Crystal structure of hPCNA bound to residues 331-350 of the flap endonuclease-1 (FEN1) | x-ray diffraction | B | — | — |
| 1U7B | Crystal structure of hpcna bound to residues 331-350 of the flap endonuclease-1 (FEN1) | x-ray diffraction | B | — | — |
| 1UL1 | Crystal structure of the human FEN1-PCNA complex | x-ray diffraction | X, Y, Z | — | — |
| 1UL1 | Crystal structure of the human FEN1-PCNA complex | x-ray diffraction | X, Y, Z | — | — |
| 3Q8K | Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with product 5'-flap DNA, SM3+… | x-ray diffraction | A | — | — |
| 3Q8K | Crystal structure of human flap endonuclease FEN1 (wt) in complex with product 5'-flap DNA, SM3+… | x-ray diffraction | A | — | — |
| 3Q8L | Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with substrate 5'-flap DNA, SM3+… | x-ray diffraction | A | — | — |
| 3Q8L | Crystal structure of human flap endonuclease FEN1 (wt) in complex with substrate 5'-flap DNA, SM3+… | x-ray diffraction | A | — | — |
| 3Q8M | Crystal Structure of Human Flap Endonuclease FEN1 (D181A) in complex with substrate 5'-flap DNA and… | x-ray diffraction | A, B | — | — |
| 3Q8M | Crystal structure of human flap endonuclease FEN1 (D181A) in complex with substrate 5'-flap DNA and… | x-ray diffraction | A, B | — | — |
| 3UVU | Structural basis of nuclear import of Flap endonuclease 1 (FEN1) | x-ray diffraction | B | — | — |
| 3UVU | Structural basis of nuclear import of flap endonuclease 1 (FEN1) | x-ray diffraction | B | — | — |
| 5FV7 | Human Fen1 in complex with an N-hydroxyurea compound | x-ray diffraction | A, B | MG, R3Z | — |
| 5FV7 | Human FEN1 in complex with an N-hydroxyurea compound | x-ray diffraction | A, B | — | — |
| 5K97 | Flap endonuclease 1 (FEN1) D233N with cleaved product fragment and Sm3+ | x-ray diffraction | A | SM, K | 6 (best 0.80) |
| 5K97 | Flap endonuclease 1 (FEN1) D233N with cleaved product fragment and SM3+ | x-ray diffraction | A | SM, K | — |
| 5KSE | Flap endonuclease 1 (FEN1) R100A with 5'-flap substrate DNA and SM3+ | x-ray diffraction | A | SM, K | — |
| 5UM9 | Flap endonuclease 1 (FEN1) D86N with 5'-flap substrate DNA and SM3+ | x-ray diffraction | A | K, SM | — |
| 5ZOD | Crystal Structure of hFen1 in apo form | x-ray diffraction | A | MG, K | — |
| 5ZOD | Crystal structure of HFEN1 in apo form | x-ray diffraction | A | MG, K | — |
| 5ZOE | Crystal Structure of D181A hFen1 in complex with DNA | x-ray diffraction | A | K | 3 (best 0.75) |
| 5ZOE | Crystal structure of D181A HFEN1 in complex with DNA | x-ray diffraction | A | K | — |
| 5ZOF | Crystal structure of D181A/R192F HFEN1 in complex with DNA | x-ray diffraction | A | K | — |
| 5ZOG | Crystal structure of R192F HFEN1 in complex with DNA | x-ray diffraction | A | — | — |
| 6TNZ | Human polymerase delta-FEN1-PCNA toolbelt | electron microscopy | H | — | — |
| 7QO1 | complex of DNA ligase I and FEN1 on PCNA and DNA | electron microscopy | Y | — | 4 (best 0.71) |
| 8YJL | Structure of the human endogenous PCNA-FEN1 complex - State B | electron microscopy | D | — | 9 (best 0.76) |
| P39748 | AlphaFold monomer V2.0 prediction for flap endonuclease 1 (P39748) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3Q8M chain B against the predicted model P39748: TM-score 0.99, RMSD 0.92 Å
- 3Q8M chain B against the predicted model P39748: TM-score 0.99, RMSD 0.92 Å
- 3Q8M chain A against the predicted model P39748: TM-score 0.98, RMSD 0.92 Å
- 3Q8M chain A against the predicted model P39748: TM-score 0.98, RMSD 0.92 Å
- 5FV7 chain B against the predicted model P39748: TM-score 0.98, RMSD 0.86 Å
- 5FV7 chain B against the predicted model P39748: TM-score 0.98, RMSD 0.86 Å
- 5ZOD chain A against the predicted model P39748: TM-score 0.98, RMSD 0.88 Å
- 5ZOD chain A against the predicted model P39748: TM-score 0.98, RMSD 0.88 Å
- 5ZOE chain A against the predicted model P39748: TM-score 0.98, RMSD 1.00 Å
- 5ZOE chain A against the predicted model P39748: TM-score 0.98, RMSD 1.00 Å
Elsewhere
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