MolNFT v1 · #81308 · protein
Crystal structure of the G202A mutant of human G-alpha-I1
3UMS · Guanine nucleotide-binding protein G(I) subunit alpha-1: “Crystal structure of the G202A mutant of human G-alpha-I1”. X-ray diffraction, 3 ligands (GDP, SO4, CL), 3 pockets (best druggability 0.70). MolNFT v1 #81308 on GenesisL1: 3D…
- PDB
- 3UMS
- Type
- protein
- Length
- 337 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(I) subunit alpha-1
- UniProt
- P63096
- Ligands
- GDP, SO4, CL
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(I) subunit alpha-1 | protein | 337 | 53% helix, 14% strand | P63096 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · chains A
- SO4 · Sulfate ion · ion · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 229 | 0.70 | 0.87 | 32 | GDP |
| 2 | 244 | 0.56 | 0.78 | 32 | empty |
| 3 | 54 | 0.29 | 0.75 | 11 | empty |
Compared structures
- 3UMS · Crystal structure of the G202A mutant of human G-alpha-i1 · the same entry in another collection · chain A against A, TM-score 1.00
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63096
- Elsewhere: RCSB PDB 3UMS · PDBe 3UMS · UniProt P63096
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