MolNFT v1 · #81246 · protein
Mouse importin alpha: mouse CBP80Y8D cnls complex
3UL0 · Importin subunit alpha-2: “Mouse importin alpha: mouse CBP80Y8D cnls complex”. X-ray diffraction, 3 pockets (best druggability 0.45). MolNFT v1 #81246 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3UL0
- Type
- protein
- Length
- 449 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-2; Nuclear cap-binding protein subunit 1
- UniProt
- P52293, Q3UYV9
- Pockets
- 3 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Importin subunit alpha-2 | protein | 426 | 73% helix, 0% strand | P52293 |
| C | Nuclear cap-binding protein subunit 1 | protein | 23 | 0% helix, 0% strand | Q3UYV9 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.45 | 0.81 | 12 | empty |
| 2 | 83 | 0.44 | 0.81 | 25 | empty |
| 3 | 52 | 0.31 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- B–C · 1486 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
- 3UL0 · Mouse importin alpha: mouse CBP80Y8D cNLS complex · the same entry in another collection · chain B against B, TM-score 1.00
- P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q3UYV9 · AlphaFold monomer V2.0 prediction for nuclear cap-binding protein subunit 1 (Q3UYV9) · a predicted model of the same protein · chain C against A, TM-score 0.17
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt Q3UYV9
- Elsewhere: RCSB PDB 3UL0 · PDBe 3UL0 · UniProt P52293 · UniProt Q3UYV9
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