MolNFT v1 · #80217 · protein
EB1C/EB3C heterodimer in complex with the cap-gly domain of P150GLUED
3TQ7 · Microtubule-associated protein RP/EB family member 1: “EB1C/EB3C heterodimer in complex with the cap-gly domain of P150GLUED”. X-ray diffraction, 1 pocket (best druggability 0.29). MolNFT v1 #80217 on GenesisL1: 3D structure…
- PDB
- 3TQ7
- Type
- protein
- Length
- 252 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein RP/EB family member 1; Microtubule-associated protein…
- UniProt
- Q15691, Q9UPY8, Q14203
- Pockets
- 1 · best druggability 0.29
Structure
x-ray diffraction · 3 distinct chains · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Microtubule-associated protein RP/EB family member 1 | protein | 55 | 67% helix, 0% strand | Q15691 |
| B | Microtubule-associated protein RP/EB family member 3 | protein | 55 | 76% helix, 2% strand | Q9UPY8 |
| P, Q | Dynactin subunit 1 | protein | 71 | 4% helix, 42% strand | Q14203 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.29 | 0.75 | 14 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1372 Ų buried · 10 hydrogen bonds · protein-protein
- A–Q · 817 Ų buried · 10 hydrogen bonds · protein-protein
- B–P · 789 Ų buried · 10 hydrogen bonds · protein-protein
- A–P · 131 Ų buried · 0 hydrogen bonds · protein-protein
- B–Q · 129 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3TQ7 · EB1c/EB3c heterodimer in complex with the CAP-Gly domain of P150glued · the same entry in another collection · chain Q against Q, TM-score 1.00
- Q14203 · AlphaFold monomer V2.0 prediction for dynactin subunit 1 (Q14203) · a predicted model of the same protein · chain Q against A, TM-score 0.97
- Q9UPY8 · AlphaFold monomer V2.0 prediction for microtubule-associated protein RP/EB family member… · a predicted model of the same protein · chain B against A, TM-score 0.88
- Q15691 · AlphaFold monomer V2.0 prediction for microtubule-associated protein RP/EB family member… · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15691
- Every structure of UniProt Q9UPY8
- Every structure of UniProt Q14203
- Elsewhere: RCSB PDB 3TQ7 · PDBe 3TQ7 · UniProt Q15691 · UniProt Q9UPY8 · UniProt Q14203
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