MolNFT v1 · #79909 · protein

Crystal structure of wild-type RAC1

3TH5 · RAS-related C3 botulinum toxin substrate 1: “Crystal structure of wild-type RAC1”. X-ray diffraction, 2 ligands (GNP, MG), 3 pockets (best druggability 0.60). MolNFT v1 #79909 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 3TH5
Type: protein
Length: 347 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RAS-related C3 botulinum toxin substrate 1
UniProt: P63000
Ligands: GNP, MG
Pockets: 3 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RAS-related C3 botulinum toxin substrate 1	protein	176	39% helix, 26% strand	P63000
B	RAS-related C3 botulinum toxin substrate 1	protein	171	39% helix, 25% strand	P63000

Ligands and binding sites

GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	167	0.60	0.83	26	empty
2	152	0.55	0.81	31	GNP, MG
3	202	0.51	0.77	26	empty

Interfaces

1 interface between chains.

A–B · 521 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

3TH5 · Crystal structure of wild-type RAC1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63000
Elsewhere: RCSB PDB 3TH5 · PDBe 3TH5 · UniProt P63000

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.