MolNFT v1 · #79719 · protein
Crystal structure of T4 GP33 bound to E. COLI rnap beta-flap domain
3TBI · RNA polymerase-associated protein GP33: “Crystal structure of T4 GP33 bound to E. COLI rnap beta-flap domain”. X-ray diffraction, 1 pocket (best druggability 0.50). MolNFT v1 #79719 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3TBI
- Type
- protein
- Length
- 299 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase-associated protein GP33; DNA-directed RNA polymerase subunit beta
- EC
- 2.7.7.6
- UniProt
- P13338, P0A8V2
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 50% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA polymerase-associated protein GP33 | protein | 71 | 73% helix, 0% strand | P13338 |
| B | DNA-directed RNA polymerase subunit beta (EC 2.7.7.6) | protein | 228 | 43% helix, 25% strand | P0A8V2 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 170 | 0.50 | 0.78 | 33 | empty |
Interfaces
1 interface between chains.
- A–B · 926 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 3TBI · Crystal structure of T4 gp33 bound to E. coli RNAP beta-flap domain · the same entry in another collection · chain A against A, TM-score 1.00
- P0A8V2 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit beta (P0A8V2) · a predicted model of the same protein · chain B against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13338
- Every structure of UniProt P0A8V2
- Elsewhere: RCSB PDB 3TBI · PDBe 3TBI · UniProt P13338 · UniProt P0A8V2
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