MolNFT v1 · #387242 · protein
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit beta (P0A8V2)
P0A8V2: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit beta (P0A8V2)”. 16 pockets (best druggability 0.76). MolNFT v1 #387242 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P0A8V2
- Type
- protein
- Length
- 1,342 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x025f3b1a898b05AD2731bE6Ab72687b5920c4A3F
- Molecule
- DNA-directed RNA polymerase subunit beta
- UniProt
- P0A8V2
- Pockets
- 16 · best druggability 0.76
Structure
1 distinct chain · 33% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase subunit beta | protein | 1342 | 33% helix, 25% strand | P0A8V2 |
Pockets
16 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1140 | 0.76 | 0.79 | 91 | empty |
| 2 | 501 | 0.74 | 0.82 | 52 | empty |
| 3 | 846 | 0.73 | 0.78 | 87 | empty |
| 4 | 55 | 0.67 | 0.96 | 18 | empty |
| 5 | 352 | 0.59 | 0.77 | 43 | empty |
Compared structures
- 5W1T · X-ray crystal structure of escherichia COLI RNA polymerase and dksa complex · an experimental structure of the same protein · chain A against C, TM-score 0.99
- 5UAC · Escherichia coli RNA polymerase and Rifampin complex, wild-type · an experimental structure of the same protein · chain A against C, TM-score 0.99
- 5UAC · Escherichia COLI RNA polymerase and rifampin complex, wild-type · an experimental structure of the same protein · chain A against C, TM-score 0.99
- 5IPM · Sigmas-transcription initiation complex with 4-nt nascent RNA · an experimental structure of the same protein · chain A against C, TM-score 0.99
- 5IPM · SigmaS-transcription initiation complex with 4-nt nascent RNA · an experimental structure of the same protein · chain A against C, TM-score 0.99
- 6UTV · E. coli sigma-S transcription initiation complex with a 6-nt RNA (Fresh" crystal soaked… · an experimental structure of the same protein · chain A against CCC, TM-score 0.99
- 5IPN · Sigmas-transcription initiation complex with 4-nt nascent RNA · an experimental structure of the same protein · chain A against C, TM-score 0.99
- 5VT0 · Escherichia COLI 6S RNA derivative in complex with escherichia COLI RNA polymerase… · an experimental structure of the same protein · chain A against I, TM-score 0.99
- 5UAJ · Escherichia COLI RNA polymerase rpob S531L mutant · an experimental structure of the same protein · chain A against I, TM-score 0.98
- 7XUE · Cryo-EM structure of HK022 putRNA-associated E.coli RNA polymerase elongation complex · an experimental structure of the same protein · chain A against I, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A8V2
- Elsewhere: UniProt P0A8V2 · AlphaFold DB P0A8V2
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