MolNFT v1 · #79550 · protein
Structure of human dppiii in complex with the opioid peptide tynorphin, at 3.0 ångströms
3T6J · Dipeptidyl peptidase 3: “Structure of human dppiii in complex with the opioid peptide tynorphin, at 3.0 ångströms”. X-ray diffraction, 6 pockets (best druggability 0.85). MolNFT v1 #79550 on GenesisL1: 3D structure, binding sites…
- PDB
- 3T6J
- Type
- protein
- Length
- 727 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dipeptidyl peptidase 3; Tynorphin
- EC
- 3.4.14.4
- UniProt
- Q9NY33
- Pockets
- 6 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dipeptidyl peptidase 3 (EC 3.4.14.4) | protein | 722 | 48% helix, 14% strand | Q9NY33 |
| B | Tynorphin | protein | 5 | 0% helix, 40% strand | — |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1176 | 0.85 | 0.86 | 121 | empty |
| 2 | 118 | 0.77 | 0.96 | 27 | empty |
| 3 | 281 | 0.67 | 0.82 | 37 | empty |
| 4 | 130 | 0.52 | 0.81 | 32 | empty |
| 5 | 62 | 0.33 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 695 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 3T6J · Structure of human DPPIII in complex with the opioid peptide Tynorphin, at 3.0 Angstroms · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NY33 · AlphaFold monomer V2.0 prediction for dipeptidyl peptidase 3 (Q9NY33) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NY33
- Elsewhere: RCSB PDB 3T6J · PDBe 3T6J · UniProt Q9NY33
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.