Research workbench
Structure of human dppiii in complex with the opioid peptide tynorphin, at 3.0 ångströms
Analyse Structure of human dppiii in complex with the opioid peptide tynorphin, at 3.0… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3T6J
- Type
- protein
- Length
- 727 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dipeptidyl peptidase 3; Tynorphin
- EC
- 3.4.14.4
- UniProt
- Q9NY33
- Pockets
- 6 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dipeptidyl peptidase 3 (EC 3.4.14.4) | protein | 722 | 48% helix, 14% strand | Q9NY33 |
| B | Tynorphin | protein | 5 | 0% helix, 40% strand | — |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1176 | 0.85 | 0.86 | 121 | empty |
| 2 | 118 | 0.77 | 0.96 | 27 | empty |
| 3 | 281 | 0.67 | 0.82 | 37 | empty |
| 4 | 130 | 0.52 | 0.81 | 32 | empty |
| 5 | 62 | 0.33 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 695 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 3T6J · Structure of human DPPIII in complex with the opioid peptide Tynorphin, at 3.0 Angstroms · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NY33 · AlphaFold monomer V2.0 prediction for dipeptidyl peptidase 3 (Q9NY33) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NY33
- Elsewhere: RCSB PDB 3T6J · PDBe 3T6J · UniProt Q9NY33
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