Crystal structure of a small conductance potassium channel splice variant complexed with calcium-calmodulin

Structure

x-ray diffraction · 4 distinct chains · 70% helix, 3% strand (DSSP).

Ligands and binding sites

• PHU · 1-phenylurea · ligand · 4 copies · chains A, C, B, D
• CA · Calcium ion · metal · 8 copies · chains A, B
• SO4 · Sulfate ion · ion · 8 copies · chains A, B, C, D
• GOL · Glycerol · additive · 6 copies · chains A, C, B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Interfaces

5 interfaces between chains.

• A–D · 1052 Ų buried · 15 hydrogen bonds · protein-protein
• B–C · 1029 Ų buried · 11 hydrogen bonds · protein-protein
• A–C · 913 Ų buried · 9 hydrogen bonds · protein-protein
• B–D · 906 Ų buried · 5 hydrogen bonds · protein-protein
• A–B · 82 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

• 3SJQ · Crystal structure of a small conductance potassium channel splice variant complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
• P70604 · AlphaFold monomer V2.0 prediction for small conductance calcium- activated potassium… · a predicted model of the same protein · chain D against A, TM-score 0.81

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P62161
• Every structure of UniProt P70604
• Elsewhere: RCSB PDB 3SJQ · PDBe 3SJQ · UniProt P62161 · UniProt P70604