MolNFT v1 · #77346 · protein
Human mitochondrial helicase SUV3
3RC3 · ATP-dependent RNA helicase SUPV3L1, mitochondrial: “Human mitochondrial helicase SUV3”. X-ray diffraction, 4 ligands (ANP, NA, AZI), 7 pockets (best druggability 0.75). MolNFT v1 #77346 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3RC3
- Type
- protein
- Length
- 607 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent RNA helicase SUPV3L1, mitochondrial
- EC
- 3.6.4.13
- UniProt
- Q8IYB8
- Ligands
- ANP, NA, AZI, CL
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) | protein | 607 | 50% helix, 13% strand | Q8IYB8 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
- NA · Sodium ion · metal · chains A
- AZI · Azide ion · ion · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 454 | 0.75 | 0.84 | 59 | ANP |
| 2 | 578 | 0.74 | 0.81 | 57 | empty |
| 3 | 84 | 0.57 | 0.86 | 14 | empty |
| 4 | 64 | 0.40 | 0.80 | 14 | empty |
| 5 | 63 | 0.35 | 0.77 | 19 | empty |
Modifications
Observed in the structure: 14 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IYB8
- Elsewhere: RCSB PDB 3RC3 · PDBe 3RC3 · UniProt Q8IYB8
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