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Human mitochondrial helicase SUV3

Analyse Human mitochondrial helicase SUV3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3RC3
Type: protein
Length: 607 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-dependent RNA helicase SUPV3L1, mitochondrial
EC: 3.6.4.13
UniProt: Q8IYB8
Ligands: ANP, NA, AZI, CL
Pockets: 7 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 50% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13)	protein	607	50% helix, 13% strand	Q8IYB8

Ligands and binding sites

ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
NA · Sodium ion · metal · chains A
AZI · Azide ion · ion · chains A
CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	454	0.75	0.84	59	ANP
2	578	0.74	0.81	57	empty
3	84	0.57	0.86	14	empty
4	64	0.40	0.80	14	empty
5	63	0.35	0.77	19	empty

Modifications

Observed in the structure: 14 modified (engineered).

Compared structures

3RC3 · Human Mitochondrial Helicase Suv3 · the same entry in another collection · chain A against A, TM-score 1.00
Q8IYB8 · AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase SUPV3L1, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IYB8
Elsewhere: RCSB PDB 3RC3 · PDBe 3RC3 · UniProt Q8IYB8

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