MolNFT v1 · #75642 · protein

Crystal structure of the E. COLI beta clamp mutant R103C, I305C, C260S, C333S at 2.2A resolution

3PWE · DNA polymerase III subunit beta: “Crystal structure of the E. COLI beta clamp mutant R103C, I305C, C260S, C333S at 2.2A resolution”. X-ray diffraction, 5 pockets (best druggability 0.44). MolNFT v1 #75642 on GenesisL1: 3D structure…

PDB: 3PWE
Type: protein
Length: 732 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA polymerase III subunit beta
EC: 2.7.7.7
UniProt: P0A988
Pockets: 5 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 22% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	DNA polymerase III subunit beta (EC 2.7.7.7)	protein	366	22% helix, 45% strand	P0A988

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	187	0.44	0.74	29	empty
2	180	0.43	0.74	26	empty
3	58	0.30	0.75	17	empty
4	66	0.30	0.74	16	empty
5	51	0.25	0.73	19	empty

Interfaces

1 interface between chains.

A–B · 1318 Å² buried · 28 hydrogen bonds · protein-protein

Compared structures

3PWE · Crystal structure of the E. coli beta clamp mutant R103C, I305C, C260S, C333S at 2.2A… · the same entry in another collection · chain A against A, TM-score 1.00
P0A988 · AlphaFold monomer V2.0 prediction for beta sliding clamp (P0A988) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A988
Elsewhere: RCSB PDB 3PWE · PDBe 3PWE · UniProt P0A988

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