MolNFT v1 · #74301 · protein
Maltose-bound maltose sensor engineered by insertion of circularly permuted green fluorescent protein into E. COLI maltose binding protein at position 175
3OSQ · Maltose-binding periplasmic PROTEIN,GREEN fluorescent…: “Maltose-bound maltose sensor engineered by insertion of circularly permuted green fluorescent protein into E.…”. X-ray diffraction, 3 ligands (C12, GLC, SO4), 5 pockets (best…
- PDB
- 3OSQ
- Type
- protein
- Length
- 607 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose-binding periplasmic PROTEIN,GREEN fluorescent protein
- UniProt
- P0AEY0, P42212
- Ligands
- C12, GLC, SO4
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose-binding periplasmic PROTEIN,GREEN fluorescent protein | protein | 607 | 32% helix, 32% strand | P0AEY0, P42212 |
Ligands and binding sites
- C12 · 2-(1-amino-2-hydroxypropyl)-4-(4-hydroxybenzyl)-1-(2-oxoethyl)-1H-imidazol-5-olate · ligand · chains A
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 444 | 0.76 | 0.85 | 61 | C12 |
| 2 | 292 | 0.70 | 0.84 | 31 | GLC |
| 3 | 253 | 0.55 | 0.77 | 30 | SO4 |
| 4 | 70 | 0.43 | 0.81 | 16 | empty |
| 5 | 73 | 0.36 | 0.77 | 20 | empty |
Modifications
Observed in the structure: 2 covalent (covalent ligand).
Compared structures
- 3OSQ · Maltose-bound maltose sensor engineered by insertion of circularly permuted green… · the same entry in another collection · chain A against A, TM-score 1.00
- P42212 · AlphaFold monomer V2.0 prediction for green fluorescent protein (P42212) · a predicted model of the same protein · chain A against A, TM-score 0.24
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEY0
- Every structure of UniProt P42212
- Elsewhere: RCSB PDB 3OSQ · PDBe 3OSQ · UniProt P0AEY0 · UniProt P42212
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