MolNFT v1 · #73939 · protein

Catalytic domain of stromelysin-1 in complex with N-hydroxy-2-(4- METHYLPHENYLSULFONAMIDO)ACETAMIDE

3OHO: “Catalytic domain of stromelysin-1 in complex with N-hydroxy-2-(4- METHYLPHENYLSULFONAMIDO)ACETAMIDE”. X-ray diffraction, 4 ligands (Z79, CA, ZN), 1 pocket (best druggability 0.53). MolNFT v1 #73939 on GenesisL1: 3D structure…

PDB: 3OHO
Type: protein
Length: 159 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Stromelysin-1
EC: 3.4.24.17
UniProt: P08254
Ligands: Z79, CA, ZN, SO4
Pockets: 1 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 23% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Stromelysin-1 (EC 3.4.24.17)	protein	159	23% helix, 19% strand	P08254

Ligands and binding sites

Z79 · N-hydroxy-N~2~-[(4-methoxyphenyl)sulfonyl]glycinamide · ligand · chains A
CA · Calcium ion · metal · 3 copies · chains A
ZN · Zinc ion · metal · 2 copies · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	182	0.53	0.79	28	ZN, Z79

Compared structures

3OHO · catalytic domain of stromelysin-1 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08254
Elsewhere: RCSB PDB 3OHO · PDBe 3OHO · UniProt P08254

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