MolNFT v1 · #71760 · protein
Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, V708A, E711G) mutations at 1.50A
3MNP: “Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, V708A, E711G)…”. X-ray diffraction, 2 ligands (DEX, SCN), 2 pockets (best druggability 0.83). MolNFT v1 #71760 on GenesisL1: 3D structure…
- PDB
- 3MNP
- Type
- protein
- Length
- 267 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucocorticoid receptor; Nuclear receptor coactivator 2 peptide
- UniProt
- P06537, Q61026
- Ligands
- DEX, SCN
- Pockets
- 2 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glucocorticoid receptor | protein | 257 | 65% helix, 5% strand | P06537 |
| B | Nuclear receptor coactivator 2 peptide | protein | 10 | 70% helix, 0% strand | Q61026 |
Ligands and binding sites
- DEX · Dexamethasone · ligand · chains A
- SCN · Thiocyanate ion · ion · 2 copies · chains A
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 176 | 0.83 | 0.97 | 23 | DEX |
| 2 | 161 | 0.66 | 0.86 | 25 | GOL |
Interfaces
1 interface between chains.
- A–B · 570 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3MNP · Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by… · the same entry in another collection · chain A against A, TM-score 1.00
- P06537 · AlphaFold monomer V2.0 prediction for glucocorticoid receptor (P06537) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q61026 · AlphaFold monomer V2.0 prediction for nuclear receptor coactivator 2 (Q61026) · a predicted model of the same protein · chain B against A, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06537
- Every structure of UniProt Q61026
- Elsewhere: RCSB PDB 3MNP · PDBe 3MNP · UniProt P06537 · UniProt Q61026
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