MolNFT v1 · #71742 · protein
Structures of actin-bound WH2 domains of spire and the implication for filament nucleation
3MN7 · Actin-5C: “Structures of actin-bound WH2 domains of spire and the implication for filament nucleation”. X-ray diffraction, 2 ligands (ATP, CA), 3 pockets (best druggability 0.76). MolNFT v1 #71742 on GenesisL1: 3D structure, binding…
- PDB
- 3MN7
- Type
- protein
- Length
- 379 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin-5C; Spire ddd
- UniProt
- P10987
- Ligands
- ATP, CA
- Pockets
- 3 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Actin-5C | protein | 359 | 44% helix, 20% strand | P10987 |
| S | Spire ddd | protein | 20 | 45% helix, 0% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 386 | 0.76 | 0.86 | 53 | ATP, CA |
| 2 | 134 | 0.57 | 0.83 | 31 | empty |
| 3 | 50 | 0.25 | 0.73 | 9 | empty |
Interfaces
1 interface between chains.
- A–S · 856 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3MN7 · Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation · the same entry in another collection · chain A against A, TM-score 1.00
- P10987 · AlphaFold monomer V2.0 prediction for actin-5C (P10987) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10987
- Elsewhere: RCSB PDB 3MN7 · PDBe 3MN7 · UniProt P10987
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