MolNFT v1 · #70723 · protein
Structure of the A237F mutant of the pentameric ligand gated ion channel from gloeobacter violaceus
3LSV · Ligand-gated ion channel: “Structure of the A237F mutant of the pentameric ligand gated ion channel from gloeobacter violaceus”. X-ray diffraction, 20 pockets (best druggability 0.83). MolNFT v1 #70723 on GenesisL1: 3D structure…
- PDB
- 3LSV
- Type
- protein
- Length
- 1,555 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ligand-gated ion channel
- UniProt
- Q7NDN8
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Ligand-gated ion channel | protein | 311 | 38% helix, 34% strand | Q7NDN8 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1023 | 0.83 | 0.83 | 56 | empty |
| 2 | 370 | 0.72 | 0.84 | 48 | empty |
| 3 | 357 | 0.72 | 0.84 | 47 | empty |
| 4 | 350 | 0.72 | 0.84 | 46 | empty |
| 5 | 112 | 0.70 | 0.92 | 29 | empty |
Interfaces
5 interfaces between chains.
- C–D · 2347 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 2339 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 2331 Ų buried · 14 hydrogen bonds · protein-protein
- D–E · 2325 Ų buried · 16 hydrogen bonds · protein-protein
- A–E · 2309 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 3LSV · Structure of the A237F mutant of the pentameric ligand gated ion channel from Gloeobacter… · the same entry in another collection · chain E against E, TM-score 1.00
- Q7NDN8 · AlphaFold monomer V2.0 prediction for proton-gated ion channel (Q7NDN8) · a predicted model of the same protein · chain D against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 3LSV · PDBe 3LSV · UniProt Q7NDN8
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