Research workbench
Structure of the A237F mutant of the pentameric ligand gated ion channel from gloeobacter violaceus
Analyse Structure of the A237F mutant of the pentameric ligand gated ion channel from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LSV
- Type
- protein
- Length
- 1,555 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ligand-gated ion channel
- UniProt
- Q7NDN8
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Ligand-gated ion channel | protein | 311 | 38% helix, 34% strand | Q7NDN8 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1023 | 0.83 | 0.83 | 56 | empty |
| 2 | 370 | 0.72 | 0.84 | 48 | empty |
| 3 | 357 | 0.72 | 0.84 | 47 | empty |
| 4 | 350 | 0.72 | 0.84 | 46 | empty |
| 5 | 112 | 0.70 | 0.92 | 29 | empty |
Interfaces
5 interfaces between chains.
- C–D · 2347 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 2339 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 2331 Ų buried · 14 hydrogen bonds · protein-protein
- D–E · 2325 Ų buried · 16 hydrogen bonds · protein-protein
- A–E · 2309 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 3LSV · Structure of the A237F mutant of the pentameric ligand gated ion channel from Gloeobacter… · the same entry in another collection · chain E against E, TM-score 1.00
- Q7NDN8 · AlphaFold monomer V2.0 prediction for proton-gated ion channel (Q7NDN8) · a predicted model of the same protein · chain D against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 3LSV · PDBe 3LSV · UniProt Q7NDN8
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