MolNFT v1 · #70424 · protein
Crystal structure of capz bound to the cpi and csi uncapping motifs from carmil
3LK3 · F-actin-capping protein subunit alpha-1: “Crystal structure of capz bound to the cpi and csi uncapping motifs from carmil”. X-ray diffraction, 9 pockets (best druggability 0.80). MolNFT v1 #70424 on GenesisL1: 3D structure, binding…
- PDB
- 3LK3
- Type
- protein
- Length
- 564 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-actin-capping protein subunit alpha-1; F-actin-capping protein subunit beta isoforms 1…
- UniProt
- P13127, P14315, Q5VZK9
- Pockets
- 9 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 38% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F-actin-capping protein subunit alpha-1 | protein | 266 | 40% helix, 34% strand | P13127 |
| B | F-actin-capping protein subunit beta isoforms 1 and 2 | protein | 249 | 40% helix, 35% strand | P14315 |
| T | Leucine-rich repeat-containing protein 16A | protein | 49 | 14% helix, 0% strand | Q5VZK9 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 119 | 0.80 | 0.98 | 19 | empty |
| 2 | 148 | 0.65 | 0.87 | 29 | empty |
| 3 | 81 | 0.58 | 0.88 | 22 | empty |
| 4 | 197 | 0.51 | 0.77 | 25 | empty |
| 5 | 58 | 0.42 | 0.82 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3984 Ų buried · 63 hydrogen bonds · protein-protein
- B–T · 1961 Ų buried · 35 hydrogen bonds · protein-protein
- A–T · 1267 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3LK3 · Crystal structure of CapZ bound to the CPI and CSI uncapping motifs from CARMIL · the same entry in another collection · chain A against A, TM-score 1.00
- P14315 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit beta isoforms 1 and… · a predicted model of the same protein · chain B against A, TM-score 0.98
- P13127 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit alpha-1 (P13127) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q5VZK9 · AlphaFold monomer V2.0 prediction for F-actin-uncapping protein LRRC16A (Q5VZK9) · a predicted model of the same protein · chain T against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13127
- Every structure of UniProt P14315
- Every structure of UniProt Q5VZK9
- Elsewhere: RCSB PDB 3LK3 · PDBe 3LK3 · UniProt P13127 · UniProt P14315 · UniProt Q5VZK9
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