Research workbench
Crystal structure of capz bound to the cpi and csi uncapping motifs from carmil
Analyse Crystal structure of capz bound to the cpi and csi uncapping motifs from carmil in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LK3
- Type
- protein
- Length
- 564 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- F-actin-capping protein subunit alpha-1; F-actin-capping protein subunit beta isoforms 1…
- UniProt
- P13127, P14315, Q5VZK9
- Pockets
- 9 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 38% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | F-actin-capping protein subunit alpha-1 | protein | 266 | 40% helix, 34% strand | P13127 |
| B | F-actin-capping protein subunit beta isoforms 1 and 2 | protein | 249 | 40% helix, 35% strand | P14315 |
| T | Leucine-rich repeat-containing protein 16A | protein | 49 | 14% helix, 0% strand | Q5VZK9 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 119 | 0.80 | 0.98 | 19 | empty |
| 2 | 148 | 0.65 | 0.87 | 29 | empty |
| 3 | 81 | 0.58 | 0.88 | 22 | empty |
| 4 | 197 | 0.51 | 0.77 | 25 | empty |
| 5 | 58 | 0.42 | 0.82 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3984 Ų buried · 63 hydrogen bonds · protein-protein
- B–T · 1961 Ų buried · 35 hydrogen bonds · protein-protein
- A–T · 1267 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3LK3 · Crystal structure of CapZ bound to the CPI and CSI uncapping motifs from CARMIL · the same entry in another collection · chain A against A, TM-score 1.00
- P14315 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit beta isoforms 1 and… · a predicted model of the same protein · chain B against A, TM-score 0.98
- P13127 · AlphaFold monomer V2.0 prediction for F-actin-capping protein subunit alpha-1 (P13127) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q5VZK9 · AlphaFold monomer V2.0 prediction for F-actin-uncapping protein LRRC16A (Q5VZK9) · a predicted model of the same protein · chain T against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13127
- Every structure of UniProt P14315
- Every structure of UniProt Q5VZK9
- Elsewhere: RCSB PDB 3LK3 · PDBe 3LK3 · UniProt P13127 · UniProt P14315 · UniProt Q5VZK9
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