MolNFT v1 · #70243 · protein

2F5 epitope scaffold ES2

3LES · RNA polymerase sigma factor: “2F5 epitope scaffold ES2”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.46). MolNFT v1 #70243 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3LES
Type: protein
Length: 356 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA polymerase sigma factor
UniProt: Q9EZJ8
Ligands: SO4
Pockets: 2 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA polymerase sigma factor	protein	179	68% helix, 0% strand	Q9EZJ8
B	RNA polymerase sigma factor	protein	177	69% helix, 0% strand	Q9EZJ8

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	137	0.46	0.77	26	empty
2	109	0.42	0.77	23	empty

Compared structures

3LES · 2F5 Epitope scaffold ES2 · the same entry in another collection · chain A against A, TM-score 1.00
Q9EZJ8 · AlphaFold monomer V2.0 prediction for RNA polymerase sigma factor siga (Q9EZJ8) · a predicted model of the same protein · chain B against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9EZJ8
Elsewhere: RCSB PDB 3LES · PDBe 3LES · UniProt Q9EZJ8

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