MolNFT v1 · #6946 · protein
Insights into scf ubiquitin ligases from the structure of the SKP1-SKP2 complex
1FS1 · Cyclin A/CDK2-associated P19: “Insights into scf ubiquitin ligases from the structure of the SKP1-SKP2 complex”. X-ray diffraction, 1 pocket (best druggability 0.75). MolNFT v1 #6946 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1FS1
- Type
- protein
- Length
- 316 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclin A/CDK2-associated P19; Cyclin A/CDK2-associated P45
- UniProt
- Q13309, P63208
- Pockets
- 1 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 60% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Cyclin A/CDK2-associated P19 | protein | 41 | 63% helix, 0% strand | Q13309 |
| B | Cyclin A/CDK2-associated P45 | protein | 116 | 60% helix, 10% strand | P63208 |
| D | Cyclin A/CDK2-associated P45 | protein | 118 | 58% helix, 10% strand | P63208 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 148 | 0.75 | 0.93 | 30 | empty |
Interfaces
3 interfaces between chains.
- A–B · 803 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 723 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 671 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 1FS1 · Insights into scf ubiquitin ligases from the structure of the SKP1-SKP2 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P63208 · AlphaFold monomer V2.0 prediction for S-phase kinase-associated protein 1 (P63208) · a predicted model of the same protein · chain D against A, TM-score 0.96
- Q13309 · AlphaFold monomer V2.0 prediction for S-phase kinase-associated protein 2 (Q13309) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13309
- Every structure of UniProt P63208
- Elsewhere: RCSB PDB 1FS1 · PDBe 1FS1 · UniProt Q13309 · UniProt P63208
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