UniProt Q13309
S-phase kinase-associated protein 2 (Q13309)
S-phase kinase-associated protein 2 (UniProt Q13309): 20 experimental structures and 1 predicted model on GenesisL1, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13309
- Protein
- S-phase kinase-associated protein 2
- Experimental structures
- 20
- Predicted models
- 1
- Pockets
- 18 · 4 records with a druggable one
Structures
21 records of Q13309 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FQV | Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex | x-ray diffraction | A, C, E, G, I, K, M, O | — | — |
| 1FQV | Insights into scf ubiquitin ligases from the structure of the SKP1-SKP2 complex | x-ray diffraction | A, C, E, G, I, K, M, O | — | — |
| 1FS1 | Insights into scf ubiquitin ligases from the structure of the SKP1-SKP2 complex | x-ray diffraction | A, C | — | — |
| 1FS1 | Insights into scf ubiquitin ligases from the structure of the SKP1-SKP2 complex | x-ray diffraction | A, C | — | — |
| 1FS2 | Insights into scf ubiquitin ligases from the structure of the SKP1-SKP2 complex | x-ray diffraction | A, C | — | — |
| 1FS2 | Insights into scf ubiquitin ligases from the structure of the SKP1-SKP2 complex | x-ray diffraction | A, C | — | — |
| 1LDK | Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex | x-ray diffraction | E | — | — |
| 1LDK | Structure of the CUL1-RBX1-SKP1-F BOXSKP2 scf ubiquitin ligase complex | x-ray diffraction | E | — | — |
| 2ASS | Crystal structure of the Skp1-Skp2-Cks1 complex | x-ray diffraction | B | — | — |
| 2ASS | Crystal structure of the SKP1-SKP2-CKS1 complex | x-ray diffraction | B | — | — |
| 2AST | Crystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide | x-ray diffraction | B | — | — |
| 2AST | Crystal structure of SKP1-SKP2-CKS1 in complex with a P27 peptide | x-ray diffraction | B | — | — |
| 7B5L | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly… | electron microscopy | T | — | — |
| 7B5L | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | T | — | — |
| 7B5M | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | T | — | — |
| 7B5R | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | T | — | — |
| 7LUO | N-terminus of SKP2 bound to cyclin a | x-ray diffraction | A, C | — | — |
| 7ZBW | CAND1-SCF-SKP2 CAND1 rolling-2 SCF engaged | electron microscopy | F | — | 6 (best 0.78) |
| 8OR0 | CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2 | electron microscopy | E | — | 5 (best 0.81) |
| 8OR3 | CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1 | electron microscopy | E | — | 4 (best 0.77) |
| Q13309 | AlphaFold monomer V2.0 prediction for S-phase kinase-associated protein 2 (Q13309) | predicted | A | — | 3 (best 0.52) |
Experiment against prediction
- 2AST chain B against the predicted model Q13309: TM-score 0.99, RMSD 0.62 Å
- 2AST chain B against the predicted model Q13309: TM-score 0.99, RMSD 0.62 Å
- 2ASS chain B against the predicted model Q13309: TM-score 0.99, RMSD 0.65 Å
- 2ASS chain B against the predicted model Q13309: TM-score 0.99, RMSD 0.65 Å
- 1FQV chain A against the predicted model Q13309: TM-score 0.99, RMSD 0.80 Å
- 1FQV chain A against the predicted model Q13309: TM-score 0.99, RMSD 0.80 Å
- 7B5L chain T against the predicted model Q13309: TM-score 0.98, RMSD 0.95 Å
- 7B5L chain T against the predicted model Q13309: TM-score 0.98, RMSD 0.95 Å
- 7B5R chain T against the predicted model Q13309: TM-score 0.98, RMSD 0.97 Å
- 7ZBW chain F against the predicted model Q13309: TM-score 0.98, RMSD 1.04 Å
Elsewhere
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