MolNFT v1 · #69034 · protein

X-ray crystal structure of tyrosine aminomutase mutant construct

3KDY · Histidine ammonia-lyase: “X-ray crystal structure of tyrosine aminomutase mutant construct”. X-ray diffraction, 9 pockets (best druggability 0.51). MolNFT v1 #69034 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3KDY
Type: protein
Length: 1,054 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Histidine ammonia-lyase
EC: 4.3.1.3
UniProt: Q8GMG0
Pockets: 9 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 56% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Histidine ammonia-lyase (EC 4.3.1.3)	protein	527	56% helix, 6% strand	Q8GMG0

Pockets

9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	176	0.51	0.78	34	empty
2	76	0.42	0.80	22	empty
3	83	0.40	0.78	19	empty
4	90	0.38	0.77	17	empty
5	72	0.31	0.74	18	empty

Interfaces

1 interface between chains.

A–B · 4896 Å² buried · 91 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (nonstandard).

Compared structures

3KDY · X-ray crystal structure of tyrosine aminomutase mutant construct · the same entry in another collection · chain A against A, TM-score 1.00
Q8GMG0 · AlphaFold monomer V2.0 prediction for mio-dependent tyrosine 2,3-aminomutase (Q8GMG0) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8GMG0
Elsewhere: RCSB PDB 3KDY · PDBe 3KDY · UniProt Q8GMG0

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