MolNFT v1 · #68423 · protein
Crystal structure of an interleukin-17 receptor complex
3JVF · Interleukin-17F: “Crystal structure of an interleukin-17 receptor complex”. X-ray diffraction, 2 ligands (NAG, CA), 9 pockets (best druggability 0.69). MolNFT v1 #68423 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3JVF
- Type
- protein
- Length
- 479 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-17F; Interleukin-17 receptor a
- UniProt
- Q96PD4, Q96F46
- Ligands
- NAG, CA
- Pockets
- 9 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 3% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-17F | protein | 104 | 4% helix, 54% strand | Q96PD4 |
| B | Interleukin-17F | protein | 104 | 4% helix, 57% strand | Q96PD4 |
| C | Interleukin-17 receptor a | protein | 271 | 3% helix, 40% strand | Q96F46 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 7 copies · chains A, C
- CA · Calcium ion · metal · chains B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 282 | 0.69 | 0.84 | 33 | empty |
| 2 | 64 | 0.59 | 0.90 | 18 | empty |
| 3 | 147 | 0.55 | 0.81 | 30 | empty |
| 4 | 213 | 0.54 | 0.78 | 35 | empty |
| 5 | 157 | 0.48 | 0.77 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2437 Ų buried · 31 hydrogen bonds · protein-protein
- B–C · 1474 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 998 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide, 6 glycan, 1 modified (disulfide, N-glycosylation, methylation).
Compared structures
- 3JVF · Crystal structure of an Interleukin-17 receptor complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q96F46 · AlphaFold monomer V2.0 prediction for interleukin-17 receptor a (Q96F46) · a predicted model of the same protein · chain C against A, TM-score 0.96
- Q96PD4 · AlphaFold monomer V2.0 prediction for interleukin-17F (Q96PD4) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96PD4
- Every structure of UniProt Q96F46
- Elsewhere: RCSB PDB 3JVF · PDBe 3JVF · UniProt Q96PD4 · UniProt Q96F46
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.