MolNFT v1 · #68357 · protein
Crystal structure of the complex formed between phospholipase A2 with beta-amyloid fragment, lys-gly-ala-ile-ile-gly-leu-met at 1.8 a resolution
3JTI · Phospholipase A2 isoform 3: “Crystal structure of the complex formed between phospholipase A2 with beta-amyloid fragment…”. X-ray diffraction, 1 ligand (CA). MolNFT v1 #68357 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3JTI
- Type
- protein
- Length
- 127 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phospholipase A2 isoform 3; Octapeptide from amyloid beta A4 protein
- EC
- 3.1.1.4
- UniProt
- P60045, P05067
- Ligands
- CA
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phospholipase A2 isoform 3 (EC 3.1.1.4) | protein | 119 | 48% helix, 11% strand | P60045 |
| B | Octapeptide from amyloid beta A4 protein | protein | 8 | 0% helix, 0% strand | P05067 |
Ligands and binding sites
- CA · Calcium ion · metal · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 494 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 3JTI · Crystal structure of the complex formed between Phospholipase A2 with beta-amyloid… · the same entry in another collection · chain A against A, TM-score 1.00
- P60045 · AlphaFold monomer V2.0 prediction for acidic phospholipase A2 3 (P60045) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P05067 · AlphaFold monomer V2.0 prediction for amyloid-beta precursor protein (P05067) · a predicted model of the same protein · chain B against A, TM-score 0.39
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60045
- Every structure of UniProt P05067
- Elsewhere: RCSB PDB 3JTI · PDBe 3JTI · UniProt P60045 · UniProt P05067
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