MolNFT v1 · #68060 · protein
Structure of TRPV1 ion channel determined by single particle electron cryo-microscopy
3J5P · Transient receptor potential cation channel subfamily V…: “Structure of TRPV1 ion channel determined by single particle electron cryo-microscopy”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #68060 on…
- PDB
- 3J5P
- Type
- protein
- Length
- 2,368 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 1
- UniProt
- O35433
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 60% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A, C, D | Transient receptor potential cation channel subfamily V member 1 | protein | 592 | 60% helix, 3% strand | O35433 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 224 | 0.82 | 0.95 | 28 | empty |
| 2 | 980 | 0.80 | 0.81 | 87 | empty |
| 3 | 970 | 0.80 | 0.81 | 86 | empty |
| 4 | 1015 | 0.80 | 0.81 | 86 | empty |
| 5 | 1003 | 0.80 | 0.81 | 83 | empty |
Interfaces
6 interfaces between chains.
- A–C · 2361 Ų buried · 8 hydrogen bonds · protein-protein
- B–A · 2357 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 2349 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 2343 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 29 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3J5P · Structure of TRPV1 ion channel determined by single particle electron cryo-microscopy · the same entry in another collection · chain B against B, TM-score 1.00
- O35433 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O35433
- Elsewhere: RCSB PDB 3J5P · PDBe 3J5P · UniProt O35433
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