MolNFT v1 · #67444 · protein
Crystal structure of pol gb delta-I4.
3IKL · DNA polymerase subunit gamma-2, mitochondrial: “Crystal structure of pol gb delta-I4.”. X-ray diffraction, 12 pockets (best druggability 0.84). MolNFT v1 #67444 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3IKL
- Type
- protein
- Length
- 728 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA polymerase subunit gamma-2, mitochondrial
- EC
- 2.7.7.7
- UniProt
- Q9UHN1
- Pockets
- 12 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA polymerase subunit gamma-2, mitochondrial (EC 2.7.7.7) | protein | 364 | 34% helix, 23% strand | Q9UHN1 |
| B | DNA polymerase subunit gamma-2, mitochondrial (EC 2.7.7.7) | protein | 364 | 32% helix, 23% strand | Q9UHN1 |
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 789 | 0.84 | 0.87 | 74 | empty |
| 2 | 780 | 0.73 | 0.78 | 86 | empty |
| 3 | 238 | 0.68 | 0.84 | 32 | empty |
| 4 | 183 | 0.64 | 0.84 | 24 | empty |
| 5 | 230 | 0.60 | 0.81 | 35 | empty |
Interfaces
1 interface between chains.
- A–B · 2069 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UHN1
- Elsewhere: RCSB PDB 3IKL · PDBe 3IKL · UniProt Q9UHN1
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