UniProt Q9UHN1
DNA polymerase subunit gamma-2, mitochondrial (Q9UHN1)
DNA polymerase subunit gamma-2, mitochondrial (UniProt Q9UHN1), EC 2.7.7.7: 32 experimental structures and 1 predicted model on GenesisL1, 197 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9UHN1
- Protein
- DNA polymerase subunit gamma-2, mitochondrial
- EC
- 2.7.7.7
- Experimental structures
- 32
- Predicted models
- 1
- Pockets
- 197 · 19 records with a druggable one
Structures
33 records of Q9UHN1 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2G4C | Crystal Structure of human DNA polymerase gamma accessory subunit | x-ray diffraction | A, B, C, D | — | — |
| 2G4C | Crystal structure of human DNA polymerase gamma accessory subunit | x-ray diffraction | A, B, C, D | — | — |
| 3IKL | Crystal structure of Pol gB delta-I4. | x-ray diffraction | A, B | — | — |
| 3IKL | Crystal structure of pol gb delta-I4. | x-ray diffraction | A, B | — | — |
| 3IKM | Crystal structure of human mitochondrial DNA polymerase holoenzyme | x-ray diffraction | B, C, E, F | — | — |
| 3IKM | Crystal structure of human mitochondrial DNA polymerase holoenzyme | x-ray diffraction | B, C, E, F | — | — |
| 4ZTU | Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase | x-ray diffraction | B, C | — | — |
| 4ZTU | Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase | x-ray diffraction | B, C | — | — |
| 4ZTZ | Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase | x-ray diffraction | B, C | — | — |
| 4ZTZ | Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase | x-ray diffraction | B, C | — | — |
| 5C51 | Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA… | x-ray diffraction | B, C | — | 8 (best 0.84) |
| 5C51 | Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA… | x-ray diffraction | B, C | — | — |
| 5C52 | Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA… | x-ray diffraction | B, C | — | — |
| 5C52 | Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA… | x-ray diffraction | B, C | — | — |
| 8D33 | Human mitochondrial DNA polymerase gamma ternary complex with GC basepair | electron microscopy | B, C | — | 11 (best 0.83) |
| 8D37 | Human mitochondrial DNA polymerase gamma ternary complex with GT basepair in replication conformer | electron microscopy | B, C | — | 12 (best 0.84) |
| 8D3R | Human mitochondrial DNA polymerase gamma ternary complex with GT basepair in intermediate conformer | electron microscopy | B, C | — | 10 (best 0.85) |
| 8D42 | Human mitochondrial DNA polymerase gamma ternary complex with GT basepair in editing conformer… | electron microscopy | B, C | — | 10 (best 0.85) |
| 8G5I | Cryo-EM structure of the Mismatch Sensing Complex (I) of Human Mitochondrial DNA Polymerase Gamma | electron microscopy | B, C | — | 9 (best 0.85) |
| 8G5J | Cryo-EM structure of the Mismatch Uncoupling Complex (II) of Human Mitochondrial DNA Polymerase… | electron microscopy | B, C | — | 11 (best 0.85) |
| 8G5K | Cryo-EM structure of the Wedge Alignment Complex (VIII) of Human Mitochondrial DNA Polymerase Gamma | electron microscopy | B, C | — | 13 (best 0.86) |
| 8G5L | Cryo-EM structure of the Primer Separation Complex (IX) of Human Mitochondrial DNA Polymerase Gamma | electron microscopy | B, C | — | 10 (best 0.82) |
| 8G5M | Cryo-EM structure of the Mismatch Locking Complex (III) of Human Mitochondrial DNA Polymerase Gamma | electron microscopy | B, C | — | 13 (best 0.84) |
| 8G5N | Cryo-EM structure of the Guide loop Engagement Complex (VI) of Human Mitochondrial DNA Polymerase… | electron microscopy | B, C | — | 6 (best 0.87) |
| 8G5O | Cryo-EM structure of the Guide loop Engagement Complex (IV) of Human Mitochondrial DNA Polymerase… | electron microscopy | B, C | — | 11 (best 0.83) |
| 8G5P | Cryo-EM structure of the Guide loop Engagement Complex (V) of Human Mitochondrial DNA Polymerase… | electron microscopy | B, C | — | 7 (best 0.85) |
| 8T7E | Cryo-EM structure of the Backtracking Initiation Complex (VII) of Human Mitochondrial DNA… | electron microscopy | B, C | — | 9 (best 0.85) |
| 8UDK | Human Mitochondrial DNA Polymerase gamma R853A Ternary Complex | x-ray diffraction | B, C | — | 11 (best 0.83) |
| 8UDL | Human Mitochondrial DNA Polymerase Gamma Binary Complex | electron microscopy | B, C | — | 10 (best 0.85) |
| 8V54 | Engaged conformation of the human mitochondrial DNA polymerase gamma bound to DNA | electron microscopy | B, C | — | 12 (best 0.85) |
| 8V55 | Human mitochondrial DNA polymerase gamma bound to a replication fork in an open conformation | electron microscopy | B, C | — | 12 (best 0.84) |
| 8V5R | Active conformation of DNA polymerase gamma bound to DNA | electron microscopy | B, C | — | 12 (best 0.84) |
| Q9UHN1 | AlphaFold monomer V2.0 prediction for DNA polymerase subunit gamma-2, mitochondrial (Q9UHN1) | predicted | A | — | — |
Experiment against prediction
- 8G5I chain C against the predicted model Q9UHN1: TM-score 0.98, RMSD 1.05 Å
- 3IKL chain A against the predicted model Q9UHN1: TM-score 0.98, RMSD 1.02 Å
- 3IKL chain A against the predicted model Q9UHN1: TM-score 0.98, RMSD 1.02 Å
- 3IKL chain B against the predicted model Q9UHN1: TM-score 0.98, RMSD 1.11 Å
- 3IKL chain B against the predicted model Q9UHN1: TM-score 0.98, RMSD 1.11 Å
- 8UDK chain C against the predicted model Q9UHN1: TM-score 0.98, RMSD 1.19 Å
- 8V5R chain C against the predicted model Q9UHN1: TM-score 0.98, RMSD 1.06 Å
- 8V55 chain B against the predicted model Q9UHN1: TM-score 0.98, RMSD 1.18 Å
- 4ZTU chain C against the predicted model Q9UHN1: TM-score 0.97, RMSD 1.22 Å
- 4ZTU chain C against the predicted model Q9UHN1: TM-score 0.97, RMSD 1.22 Å
Elsewhere
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