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Crystal structure of pol gb delta-I4.

Analyse Crystal structure of pol gb delta-I4. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3IKL
Type: protein
Length: 728 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA polymerase subunit gamma-2, mitochondrial
EC: 2.7.7.7
UniProt: Q9UHN1
Pockets: 12 · best druggability 0.84

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA polymerase subunit gamma-2, mitochondrial (EC 2.7.7.7)	protein	364	34% helix, 23% strand	Q9UHN1
B	DNA polymerase subunit gamma-2, mitochondrial (EC 2.7.7.7)	protein	364	32% helix, 23% strand	Q9UHN1

Pockets

12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	789	0.84	0.87	74	empty
2	780	0.73	0.78	86	empty
3	238	0.68	0.84	32	empty
4	183	0.64	0.84	24	empty
5	230	0.60	0.81	35	empty

Interfaces

1 interface between chains.

A–B · 2069 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

3IKL · Crystal structure of Pol gB delta-I4. · the same entry in another collection · chain A against A, TM-score 1.00
Q9UHN1 · AlphaFold monomer V2.0 prediction for DNA polymerase subunit gamma-2, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UHN1
Elsewhere: RCSB PDB 3IKL · PDBe 3IKL · UniProt Q9UHN1

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