MolNFT v1 · #66911 · protein
NUP107(AA658-925)/NUP133(AA517-1156) complex, H.SAPIENS
3I4R · Nuclear pore complex protein NUP107: “NUP107(AA658-925)/NUP133(AA517-1156) complex, H.SAPIENS”. X-ray diffraction, 7 pockets (best druggability 0.78). MolNFT v1 #66911 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3I4R
- Type
- protein
- Length
- 775 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear pore complex protein NUP107; Nuclear pore complex protein NUP133
- UniProt
- P57740, Q8WUM0
- Pockets
- 7 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 58% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear pore complex protein NUP107 | protein | 247 | 73% helix, 0% strand | P57740 |
| B | Nuclear pore complex protein NUP133 | protein | 528 | 51% helix, 0% strand | Q8WUM0 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 934 | 0.78 | 0.81 | 145 | empty |
| 2 | 341 | 0.62 | 0.78 | 41 | empty |
| 3 | 72 | 0.51 | 0.84 | 13 | empty |
| 4 | 189 | 0.50 | 0.76 | 33 | empty |
| 5 | 121 | 0.41 | 0.75 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 1185 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 3I4R · Nup107(aa658-925)/Nup133(aa517-1156) complex, H.sapiens · the same entry in another collection · chain A against A, TM-score 1.00
- P57740 · AlphaFold monomer V2.0 prediction for nuclear pore complex protein NUP107 (P57740) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q8WUM0 · AlphaFold monomer V2.0 prediction for nuclear pore complex protein NUP133 (Q8WUM0) · a predicted model of the same protein · chain B against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P57740
- Every structure of UniProt Q8WUM0
- Elsewhere: RCSB PDB 3I4R · PDBe 3I4R · UniProt P57740 · UniProt Q8WUM0
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