MolNFT v1 · #65819 · protein
Molecular basis for the association of pipki gamma-P90 with the clathrin adaptor ap-2
3H85 · Ap-2 complex subunit mu-1: “Molecular basis for the association of pipki gamma-P90 with the clathrin adaptor ap-2”. X-ray diffraction, 1 ligand (NI), 2 pockets (best druggability 0.48). MolNFT v1 #65819 on GenesisL1: 3D structure…
- PDB
- 3H85
- Type
- protein
- Length
- 261 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ap-2 complex subunit mu-1; Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
- EC
- 2.7.1.68
- UniProt
- P84092, O60331
- Ligands
- NI
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 56% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ap-2 complex subunit mu-1 | protein | 253 | 2% helix, 57% strand | P84092 |
| P | Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) | protein | 8 | 0% helix, 25% strand | O60331 |
Ligands and binding sites
- NI · Nickel (II) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 135 | 0.48 | 0.78 | 20 | empty |
| 2 | 78 | 0.35 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–P · 621 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3H85 · Molecular basis for the association of PIPKI gamma-p90 with the clathrin adaptor AP-2 · the same entry in another collection · chain A against A, TM-score 1.00
- P84092 · AlphaFold monomer V2.0 prediction for ap-2 complex subunit mu (P84092) · a predicted model of the same protein · chain A against A, TM-score 0.96
- O60331 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4-phosphate 5-kinase type-1… · a predicted model of the same protein · chain P against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P84092
- Every structure of UniProt O60331
- Elsewhere: RCSB PDB 3H85 · PDBe 3H85 · UniProt P84092 · UniProt O60331
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