MolNFT v1 · #65795 · protein
Crystal structure of the human transcription elongation factor dsif, HSPT4/HSPT5 (176-273)
3H7H · Transcription elongation factor SPT4: “Crystal structure of the human transcription elongation factor dsif, HSPT4/HSPT5 (176-273)”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.40). MolNFT v1 #65795 on GenesisL1…
- PDB
- 3H7H
- Type
- protein
- Length
- 213 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription elongation factor SPT4; Transcription elongation factor SPT5
- UniProt
- P63272, O00267
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription elongation factor SPT4 | protein | 118 | 32% helix, 22% strand | P63272 |
| B | Transcription elongation factor SPT5 | protein | 95 | 37% helix, 21% strand | O00267 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 134 | 0.40 | 0.74 | 28 | BME |
Interfaces
1 interface between chains.
- A–B · 1517 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 3H7H · Crystal structure of the human transcription elongation factor DSIF, hSpt4/hSpt5 (176-273) · the same entry in another collection · chain A against A, TM-score 1.00
- P63272 · AlphaFold monomer V2.0 prediction for transcription elongation factor SPT4 (P63272) · a predicted model of the same protein · chain A against A, TM-score 0.99
- O00267 · AlphaFold monomer V2.0 prediction for transcription elongation factor SPT5 (O00267) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63272
- Every structure of UniProt O00267
- Elsewhere: RCSB PDB 3H7H · PDBe 3H7H · UniProt P63272 · UniProt O00267
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