MolNFT v1 · #435833 · protein
AlphaFold monomer V2.0 prediction for transcription elongation factor SPT5 (O00267)
O00267: “AlphaFold monomer V2.0 prediction for transcription elongation factor SPT5 (O00267)”. 6 pockets (best druggability 0.73). MolNFT v1 #435833 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O00267
- Type
- protein
- Length
- 1,087 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xbf7aa094509dBFC080EfED6A5C99EdA11E607625
- Molecule
- Transcription elongation factor SPT5
- UniProt
- O00267
- Pockets
- 6 · best druggability 0.73
Structure
1 distinct chain · 11% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription elongation factor SPT5 | protein | 1087 | 11% helix, 22% strand | O00267 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 895 | 0.73 | 0.77 | 72 | empty |
| 2 | 500 | 0.70 | 0.80 | 44 | empty |
| 3 | 243 | 0.51 | 0.75 | 31 | empty |
| 4 | 147 | 0.44 | 0.76 | 19 | empty |
| 5 | 106 | 0.39 | 0.76 | 18 | empty |
Compared structures
- 7YCX · The structure of INTAC-PEC complex · an experimental structure of the same protein · chain A against j, TM-score 0.29
- 5OIK · Structure of an RNA polymerase II-DSIF transcription elongation complex · an experimental structure of the same protein · chain A against Z, TM-score 0.28
- 5OIK · Structure of an RNA polymerase II-dsif transcription elongation complex · an experimental structure of the same protein · chain A against Z, TM-score 0.28
- 8P4F · Structural insights into human co-transcriptional capping - structure 6 · an experimental structure of the same protein · chain A against Z, TM-score 0.28
- 7UND · Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) · an experimental structure of the same protein · chain A against Z, TM-score 0.28
- 9EGY · RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27 · an experimental structure of the same protein · chain A against Z, TM-score 0.28
- 9EGX · RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27 · an experimental structure of the same protein · chain A against Z, TM-score 0.28
- 9EH0 · RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, 30 bp upstream · an experimental structure of the same protein · chain A against Z, TM-score 0.28
- 9EGZ · RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27 · an experimental structure of the same protein · chain A against Z, TM-score 0.28
- 9EH2 · RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream · an experimental structure of the same protein · chain A against Z, TM-score 0.28
- 8A3Y · Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex · an experimental structure of the same protein · chain A against Z, TM-score 0.28
- 6TED · Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers… · an experimental structure of the same protein · chain A against Z, TM-score 0.28
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00267
- Elsewhere: UniProt O00267 · AlphaFold DB O00267
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