UniProt P63272
Transcription elongation factor SPT4 (P63272)
Transcription elongation factor SPT4 (UniProt P63272): 26 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P63272
- Protein
- Transcription elongation factor SPT4
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 11 · 8 records with a druggable one
Structures
27 records of P63272 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3H7H | Crystal structure of the human transcription elongation factor DSIF, hSpt4/hSpt5 (176-273) | x-ray diffraction | A | ZN | 1 (best 0.40) |
| 3H7H | Crystal structure of the human transcription elongation factor dsif, HSPT4/HSPT5 (176-273) | x-ray diffraction | A | ZN | 1 (best 0.40) |
| 5OIK | Structure of an RNA polymerase II-DSIF transcription elongation complex | electron microscopy | Y | ZN | — |
| 5OIK | Structure of an RNA polymerase II-dsif transcription elongation complex | electron microscopy | Y | ZN | — |
| 6GMH | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 | electron microscopy | Y | ZN | — |
| 6GMH | Structure of activated transcription complex pol II-dsif-paf-SPT6 | electron microscopy | Y | ZN | — |
| 6GML | Structure of paused transcription complex pol II-dsif-nelf | electron microscopy | Y | ZN | — |
| 6TED | Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric… | electron microscopy | Y | ZN | 1 (best 0.75) |
| 6TED | Structure of complete, activated transcription complex pol II-dsif- paf-SPT6 uncovers allosteric… | electron microscopy | Y | ZN | — |
| 7OKY | Structure of active transcription elongation complex Pol II-DSIF-ELL2-EAF1(composite structure) | electron microscopy | Y | ZN | — |
| 7OKY | Structure of active transcription elongation complex pol II-dsif-ELL2- EAF1(COMPOSITE structure) | electron microscopy | Y | ZN | — |
| 7UND | Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) | electron microscopy | Y | ZN | — |
| 7YCX | The structure of INTAC-PEC complex | electron microscopy | i | — | 1 (best 0.79) |
| 8P4C | Structural insights into human co-transcriptional capping - structure 3 | electron microscopy | Y | ZN | — |
| 8P4D | Structural insights into human co-transcriptional capping - structure 4 | electron microscopy | Y | ZN | — |
| 8P4F | Structural insights into human co-transcriptional capping - structure 6 | electron microscopy | Y | ZN | — |
| 8UHA | Structure of paused transcription complex Pol II-DSIF-NELF - tilted | electron microscopy | Y | ZN | — |
| 8UHD | Structure of paused transcription complex Pol II-DSIF-NELF - post-translocated | electron microscopy | Y | ZN | 1 (best 0.77) |
| 8W8E | human co-transcriptional RNA capping enzyme RNGTT | electron microscopy | Y | ZN | — |
| 8W8F | human co-transcriptional RNA capping enzyme RNGTT-CMTR1 | electron microscopy | Y | ZN | — |
| 9EGX | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27 | electron microscopy | Y | ZN | 1 (best 0.77) |
| 9EGY | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27 | electron microscopy | Y | ZN | 1 (best 0.75) |
| 9EGZ | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27 | electron microscopy | Y | ZN | — |
| 9EH0 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, 30 bp upstream | electron microscopy | Y | ZN | 1 (best 0.76) |
| 9EH1 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, 20 bp upstream | electron microscopy | Y | ZN | 1 (best 0.76) |
| 9EH2 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream | electron microscopy | Y | ZN | 1 (best 0.83) |
| P63272 | AlphaFold monomer V2.0 prediction for transcription elongation factor SPT4 (P63272) | predicted | A | — | 1 (best 0.29) |
Ligands
- ZN · Zinc ion · in 25 records
Experiment against prediction
- 5OIK chain Y against the predicted model P63272: TM-score 1.00, RMSD 0.24 Å
- 5OIK chain Y against the predicted model P63272: TM-score 1.00, RMSD 0.24 Å
- 8P4F chain Y against the predicted model P63272: TM-score 1.00, RMSD 0.24 Å
- 3H7H chain A against the predicted model P63272: TM-score 0.99, RMSD 0.30 Å
- 3H7H chain A against the predicted model P63272: TM-score 0.99, RMSD 0.30 Å
- 6GMH chain Y against the predicted model P63272: TM-score 0.99, RMSD 0.35 Å
- 6GMH chain Y against the predicted model P63272: TM-score 0.99, RMSD 0.35 Å
- 8UHD chain Y against the predicted model P63272: TM-score 0.98, RMSD 0.56 Å
- 8W8F chain Y against the predicted model P63272: TM-score 0.98, RMSD 0.58 Å
- 8W8E chain Y against the predicted model P63272: TM-score 0.98, RMSD 0.59 Å
Elsewhere
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