Catalytic domain of human SERINE/THREONINE phosphatase 5 (PP5C) with two MN2+ atoms originally soaked with norcantharidin (which is present in the structure in the hydrolyzed form)

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 21% strand (DSSP).

Ligands and binding sites

• ENL · (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid · ligand · 2 copies · chains A, D
• MN · Manganese (II) ion · metal · 4 copies · chains A, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–D · 169 Ų buried · 1 hydrogen bond · protein-protein

Compared structures

• 3H61 · Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Mn2+ atoms… · the same entry in another collection · chain A against A, TM-score 1.00
• P53041 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 5 (P53041) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P53041
• Elsewhere: RCSB PDB 3H61 · PDBe 3H61 · UniProt P53041