MolNFT v1 · #65395 · protein
Structure and RNA binding of the mouse pumilio-2 puf domain
3GVT · Pumilio homolog 2: “Structure and RNA binding of the mouse pumilio-2 puf domain”. X-ray diffraction, 5 pockets (best druggability 0.82). MolNFT v1 #65395 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3GVT
- Type
- protein
- Length
- 684 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pumilio homolog 2
- UniProt
- Q80U58
- Pockets
- 5 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 70% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Pumilio homolog 2 | protein | 342 | 70% helix, 1% strand | Q80U58 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A
- DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1200 | 0.82 | 0.83 | 93 | empty |
| 2 | 326 | 0.55 | 0.75 | 33 | empty |
| 3 | 273 | 0.54 | 0.76 | 31 | empty |
| 4 | 264 | 0.50 | 0.74 | 25 | empty |
| 5 | 220 | 0.49 | 0.75 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 1135 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q80U58
- Elsewhere: RCSB PDB 3GVT · PDBe 3GVT · UniProt Q80U58
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