MolNFT v1 · #65180 · protein
Crystal structure analysis of PKC (alpha)-C2 domain complexed with CA2+ and PTDINS(4,5)P2
3GPE · Protein kinase C alpha type: “Crystal structure analysis of PKC (alpha)-C2 domain complexed with CA2+ and PTDINS(4,5)P2”. X-ray diffraction, 3 ligands (PT5, CA, PO4). MolNFT v1 #65180 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3GPE
- Type
- protein
- Length
- 137 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein kinase C alpha type
- EC
- 2.7.11.13
- UniProt
- P05696
- Ligands
- PT5, CA, PO4
Structure
x-ray diffraction · 1 distinct chain · 10% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein kinase C alpha type (EC 2.7.11.13) | protein | 137 | 10% helix, 47% strand | P05696 |
Ligands and binding sites
- PT5 · (1S)-2-{[(R)-hydroxy{[(1r,2r,3s,4r,5r,6s)-2,3,6-trihydroxy-4,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy) methyl]ethyl (8E,11E)-icosa-5,8,11,14-tetraenoate · ligand · chains A
- CA · Calcium ion · metal · 3 copies · chains A
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 3GPE · Crystal Structure Analysis of PKC (alpha)-C2 domain complexed with Ca2+ and PtdIns(4,5)P2 · the same entry in another collection · chain A against A, TM-score 1.00
- P05696 · AlphaFold monomer V2.0 prediction for protein kinase C alpha type (P05696) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05696
- Elsewhere: RCSB PDB 3GPE · PDBe 3GPE · UniProt P05696
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