UniProt P05696
Protein kinase C alpha type (P05696)
Protein kinase C alpha type (UniProt P05696), EC 2.7.11.13: 14 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P05696
- Protein
- Protein kinase C alpha type
- EC
- 2.7.11.13
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 1 · 0 records with a druggable one
Structures
15 records of P05696 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DSY | C2 domain from protein kinase C (alpha) complexed with CA2+ and phosphatidylserine | x-ray diffraction | A | — | — |
| 1DSY | C2 domain from protein kinase C (alpha) complexed with CA2+ and phosphatidylserine | x-ray diffraction | A | — | — |
| 2NCE | Solution Structure of Ca2+-bound C2 domain from Protein Kinase C alpha in the form of complex with… | solution nmr | A | — | — |
| 2NCE | Solution structure of CA2+-bound C2 domain from protein kinase C alpha in the form of complex with… | solution nmr | A | — | — |
| 3GPE | Crystal Structure Analysis of PKC (alpha)-C2 domain complexed with Ca2+ and PtdIns(4,5)P2 | x-ray diffraction | A | — | — |
| 3GPE | Crystal structure analysis of PKC (alpha)-C2 domain complexed with CA2+ and PTDINS(4,5)P2 | x-ray diffraction | A | — | — |
| 3RDJ | Rat PKC C2 domain Apo | x-ray diffraction | A | — | — |
| 3RDJ | Rat PKC C2 domain apo | x-ray diffraction | A | — | — |
| 3TWY | Rat PKC C2 domain bound to pb | x-ray diffraction | A | — | — |
| 3TWY | Rat PKC C2 domain bound to pb | x-ray diffraction | A | — | — |
| 4L1L | Rat PKC C2 domain bound to CD | x-ray diffraction | A | — | — |
| 4L1L | Rat PKC C2 domain bound to CD | x-ray diffraction | A | — | — |
| 5W4S | Solution structure of C2 domain from protein kinase C alpha in ternary complex with calcium and… | solution nmr | A | CA | 1 (best 0.30) |
| 5W4S | Solution structure of C2 domain from protein kinase C alpha in ternary complex with calcium and… | solution nmr | A | ACE, NH2, CA | — |
| P05696 | AlphaFold monomer V2.0 prediction for protein kinase C alpha type (P05696) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3GPE chain A against the predicted model P05696: TM-score 0.98, RMSD 0.78 Å
- 3GPE chain A against the predicted model P05696: TM-score 0.98, RMSD 0.78 Å
- 1DSY chain A against the predicted model P05696: TM-score 0.98, RMSD 0.67 Å
- 1DSY chain A against the predicted model P05696: TM-score 0.98, RMSD 0.67 Å
- 3TWY chain A against the predicted model P05696: TM-score 0.98, RMSD 1.02 Å
- 3TWY chain A against the predicted model P05696: TM-score 0.98, RMSD 1.02 Å
- 4L1L chain A against the predicted model P05696: TM-score 0.98, RMSD 0.90 Å
- 4L1L chain A against the predicted model P05696: TM-score 0.98, RMSD 0.90 Å
- 3RDJ chain A against the predicted model P05696: TM-score 0.97, RMSD 1.01 Å
- 3RDJ chain A against the predicted model P05696: TM-score 0.97, RMSD 1.01 Å
Elsewhere
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