MolNFT v1 · #64732 · protein
Crystal structure of ARRESTIN2S and clathrin
3GC3 · Beta-arrestin-1: “Crystal structure of ARRESTIN2S and clathrin”. X-ray diffraction, 6 pockets (best druggability 0.75). MolNFT v1 #64732 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3GC3
- Type
- protein
- Length
- 678 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-arrestin-1; Clathrin heavy chain 1
- UniProt
- P17870, P49951
- Pockets
- 6 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-arrestin-1 | protein | 329 | 2% helix, 52% strand | P17870 |
| B | Clathrin heavy chain 1 | protein | 349 | 9% helix, 52% strand | P49951 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 669 | 0.75 | 0.81 | 74 | empty |
| 2 | 586 | 0.67 | 0.77 | 58 | empty |
| 3 | 188 | 0.59 | 0.81 | 34 | empty |
| 4 | 97 | 0.46 | 0.80 | 19 | empty |
| 5 | 76 | 0.32 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1151 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3GC3 · Crystal Structure of Arrestin2S and Clathrin · the same entry in another collection · chain A against A, TM-score 1.00
- P49951 · AlphaFold monomer V2.0 prediction for clathrin heavy chain 1 (P49951) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P17870 · AlphaFold monomer V2.0 prediction for beta-arrestin-1 (P17870) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17870
- Every structure of UniProt P49951
- Elsewhere: RCSB PDB 3GC3 · PDBe 3GC3 · UniProt P17870 · UniProt P49951
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