MolNFT v1 · #62712 · protein

Crystal structure of human CGI121

3ENP · TP53RK-binding protein: “Crystal structure of human CGI121”. X-ray diffraction, 5 pockets (best druggability 0.79). MolNFT v1 #62712 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3ENP
Type: protein
Length: 344 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TP53RK-binding protein
UniProt: Q9Y3C4
Pockets: 5 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TP53RK-binding protein	protein	172	45% helix, 16% strand	Q9Y3C4
B	TP53RK-binding protein	protein	172	46% helix, 15% strand	Q9Y3C4

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	595	0.79	0.85	43	empty
2	112	0.44	0.78	17	empty
3	112	0.42	0.77	18	empty
4	64	0.37	0.78	17	empty
5	76	0.34	0.75	22	empty

Interfaces

1 interface between chains.

A–B · 749 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 modified, 1 disulfide (engineered, disulfide).

Compared structures

3ENP · Crystal structure of human cgi121 · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y3C4 · AlphaFold monomer V2.0 prediction for EKC/KEOPS complex subunit tprkb (Q9Y3C4) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y3C4
Elsewhere: RCSB PDB 3ENP · PDBe 3ENP · UniProt Q9Y3C4

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