MolNFT v1 · #62519 · protein
Structure of the E221A mutant of the gloebacter violaceus pentameric ligand gated ion channnel (glic)
3EI0 · GLR4197 protein: “Structure of the E221A mutant of the gloebacter violaceus pentameric ligand gated ion channnel (glic)”. X-ray diffraction, 20 pockets (best druggability 0.81). MolNFT v1 #62519 on GenesisL1: 3D structure, binding…
- PDB
- 3EI0
- Type
- protein
- Length
- 1,550 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GLR4197 protein
- UniProt
- Q7NDN8
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | GLR4197 protein | protein | 310 | 35% helix, 27% strand | Q7NDN8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 917 | 0.81 | 0.83 | 59 | empty |
| 2 | 75 | 0.72 | 0.96 | 19 | empty |
| 3 | 74 | 0.70 | 0.95 | 18 | empty |
| 4 | 75 | 0.69 | 0.94 | 19 | empty |
| 5 | 300 | 0.68 | 0.83 | 41 | empty |
Interfaces
5 interfaces between chains.
- B–C · 2173 Ų buried · 14 hydrogen bonds · protein-protein
- D–E · 2171 Ų buried · 15 hydrogen bonds · protein-protein
- A–E · 2156 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 2133 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 2127 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 3EI0 · Structure of the E221A mutant of the Gloebacter violaceus pentameric ligand gated ion… · the same entry in another collection · chain E against E, TM-score 1.00
- Q7NDN8 · AlphaFold monomer V2.0 prediction for proton-gated ion channel (Q7NDN8) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 3EI0 · PDBe 3EI0 · UniProt Q7NDN8
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