Research workbench
Structure of the E221A mutant of the gloebacter violaceus pentameric ligand gated ion channnel (glic)
Analyse Structure of the E221A mutant of the gloebacter violaceus pentameric ligand… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3EI0
- Type
- protein
- Length
- 1,550 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GLR4197 protein
- UniProt
- Q7NDN8
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | GLR4197 protein | protein | 310 | 35% helix, 27% strand | Q7NDN8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 917 | 0.81 | 0.83 | 59 | empty |
| 2 | 75 | 0.72 | 0.96 | 19 | empty |
| 3 | 74 | 0.70 | 0.95 | 18 | empty |
| 4 | 75 | 0.69 | 0.94 | 19 | empty |
| 5 | 300 | 0.68 | 0.83 | 41 | empty |
Interfaces
5 interfaces between chains.
- B–C · 2173 Ų buried · 14 hydrogen bonds · protein-protein
- D–E · 2171 Ų buried · 15 hydrogen bonds · protein-protein
- A–E · 2156 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 2133 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 2127 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 3EI0 · Structure of the E221A mutant of the Gloebacter violaceus pentameric ligand gated ion… · the same entry in another collection · chain E against E, TM-score 1.00
- Q7NDN8 · AlphaFold monomer V2.0 prediction for proton-gated ion channel (Q7NDN8) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 3EI0 · PDBe 3EI0 · UniProt Q7NDN8
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