MolNFT v1 · #61556 · protein
Crystal structure of the binding domain of the AMPA subunit GLUR3 bound to AMPA
3DP4 · Glutamate receptor 3: “Crystal structure of the binding domain of the AMPA subunit GLUR3 bound to AMPA”. X-ray diffraction, 2 ligands (AMQ, ZN), 3 pockets (best druggability 0.73). MolNFT v1 #61556 on GenesisL1: 3D structure…
- PDB
- 3DP4
- Type
- protein
- Length
- 258 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 3
- UniProt
- P19492
- Ligands
- AMQ, ZN
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor 3 | protein | 258 | 38% helix, 22% strand | P19492 |
Ligands and binding sites
- AMQ · (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid · ligand · chains A
- ZN · Zinc ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.73 | 0.99 | 18 | AMQ |
| 2 | 99 | 0.41 | 0.77 | 19 | empty |
| 3 | 59 | 0.35 | 0.78 | 21 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3DP4 · Crystal structure of the binding domain of the AMPA subunit GluR3 bound to AMPA · the same entry in another collection · chain A against A, TM-score 1.00
- P19492 · AlphaFold monomer V2.0 prediction for glutamate receptor 3 (P19492) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19492
- Elsewhere: RCSB PDB 3DP4 · PDBe 3DP4 · UniProt P19492
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