MolNFT v1 · #61541 · protein
Crystal structure of the complex between TFB5 and the C-terminal domain of TFB2
3DOM · RNA polymerase II transcription factor B subunit 2: “Crystal structure of the complex between TFB5 and the C-terminal domain of TFB2”. X-ray diffraction, 2 pockets (best druggability 0.46). MolNFT v1 #61541 on GenesisL1: 3D…
- PDB
- 3DOM
- Type
- protein
- Length
- 273 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase II transcription factor B subunit 2; RNA polymerase II transcription…
- UniProt
- Q02939, Q3E7C1
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 4 distinct chains · 49% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA polymerase II transcription factor B subunit 2 | protein | 73 | 55% helix, 26% strand | Q02939 |
| B | RNA polymerase II transcription factor B subunit 5 | protein | 58 | 48% helix, 33% strand | Q3E7C1 |
| C | RNA polymerase II transcription factor B subunit 2 | protein | 77 | 51% helix, 23% strand | Q02939 |
| D | RNA polymerase II transcription factor B subunit 5 | protein | 65 | 43% helix, 28% strand | Q3E7C1 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 132 | 0.46 | 0.77 | 25 | empty |
| 2 | 54 | 0.33 | 0.77 | 11 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1215 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 1129 Ų buried · 20 hydrogen bonds · protein-protein
- B–D · 318 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 3DOM · Crystal Structure of the complex between Tfb5 and the C-terminal domain of Tfb2 · the same entry in another collection · chain D against D, TM-score 1.00
- Q3E7C1 · AlphaFold monomer V2.0 prediction for general transcription and DNA repair factor iih… · a predicted model of the same protein · chain B against A, TM-score 0.93
- Q02939 · AlphaFold monomer V2.0 prediction for general transcription and DNA repair factor iih… · a predicted model of the same protein · chain A against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02939
- Every structure of UniProt Q3E7C1
- Elsewhere: RCSB PDB 3DOM · PDBe 3DOM · UniProt Q02939 · UniProt Q3E7C1
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