MolNFT v1 · #61161 · protein

Crystal structure of NORE1A in complex with RAS

3DDC · GTPase HRAS: “Crystal structure of NORE1A in complex with RAS”. X-ray diffraction, 2 ligands (GNP, MG), 2 pockets (best druggability 0.65). MolNFT v1 #61161 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3DDC
Type: protein
Length: 299 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GTPase HRAS; RAS association domain-containing family protein 5
EC: 3.6.5.2
UniProt: P01112, Q5EBH1
Ligands: GNP, MG
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	GTPase HRAS (EC 3.6.5.2)	protein	166	39% helix, 27% strand	P01112
B	RAS association domain-containing family protein 5	protein	133	31% helix, 39% strand	Q5EBH1

Ligands and binding sites

GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	216	0.65	0.84	36	MG, GNP
2	200	0.49	0.76	31	empty

Interfaces

1 interface between chains.

A–B · 847 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

3DDC · Crystal Structure of NORE1A in Complex with RAS · the same entry in another collection · chain A against A, TM-score 1.00
Q5EBH1 · AlphaFold monomer V2.0 prediction for RAS association domain- containing protein 5… · a predicted model of the same protein · chain B against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01112
Every structure of UniProt Q5EBH1
Elsewhere: RCSB PDB 3DDC · PDBe 3DDC · UniProt P01112 · UniProt Q5EBH1

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