MolNFT v1 · #61078 · protein
Structure of the actin-depolymerizing factor homology domain in complex with actin
3DAW · Actin, alpha skeletal muscle: “Structure of the actin-depolymerizing factor homology domain in complex with actin”. X-ray diffraction, 2 ligands (ATP, CA), 3 pockets (best druggability 0.74). MolNFT v1 #61078 on GenesisL1: 3D…
- PDB
- 3DAW
- Type
- protein
- Length
- 512 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin, alpha skeletal muscle; Twinfilin-1
- UniProt
- P68135, Q91YR1
- Ligands
- ATP, CA
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Actin, alpha skeletal muscle | protein | 372 | 41% helix, 20% strand | P68135 |
| B | Twinfilin-1 | protein | 140 | 33% helix, 31% strand | Q91YR1 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 509 | 0.74 | 0.83 | 60 | CA, ATP |
| 2 | 160 | 0.65 | 0.85 | 30 | empty |
| 3 | 285 | 0.63 | 0.80 | 40 | empty |
Interfaces
1 interface between chains.
- A–B · 1273 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 3DAW · Structure of the actin-depolymerizing factor homology domain in complex with actin · the same entry in another collection · chain A against A, TM-score 1.00
- Q91YR1 · AlphaFold monomer V2.0 prediction for twinfilin-1 (Q91YR1) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P68135 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68135) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68135
- Every structure of UniProt Q91YR1
- Elsewhere: RCSB PDB 3DAW · PDBe 3DAW · UniProt P68135 · UniProt Q91YR1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.