MolNFT v1 · #60584 · protein

Crystal structure of the intact archaeal translation initiation factor 2 from sulfolobus solfataricus .

3CW2 · Translation initiation factor 2 subunit gamma: “Crystal structure of the intact archaeal translation initiation factor 2 from sulfolobus solfataricus .”. X-ray diffraction, 20 pockets (best druggability 0.82). MolNFT v1 #60584 on…

PDB: 3CW2
Type: protein
Length: 3,023 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Translation initiation factor 2 subunit gamma; Translation initiation factor 2 subunit…
UniProt: Q980A5, Q97Z79, Q97W59
Pockets: 20 · best druggability 0.82

Structure

x-ray diffraction · 7 distinct chains · 18% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, E, F	Translation initiation factor 2 subunit gamma	protein	414	10% helix, 30% strand	Q980A5
B	Translation initiation factor 2 subunit gamma	protein	400	15% helix, 30% strand	Q980A5
C, D, G, H	Translation initiation factor 2 subunit alpha	protein	266	40% helix, 20% strand	Q97Z79
K	Translation initiation factor 2 subunit beta	protein	128	11% helix, 0% strand	Q97W59
L	Translation initiation factor 2 subunit beta	protein	21	19% helix, 0% strand	Q97W59
M	Translation initiation factor 2 subunit beta	protein	138	11% helix, 1% strand	Q97W59
N	Translation initiation factor 2 subunit beta	protein	30	23% helix, 0% strand	Q97W59

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1161	0.82	0.83	117	empty
2	996	0.79	0.81	80	empty
3	315	0.78	0.89	51	empty
4	843	0.78	0.81	56	empty
5	856	0.77	0.80	69	empty

Interfaces

19 interfaces between chains.

E–M · 1149 Å² buried · 11 hydrogen bonds · protein-protein
A–K · 1147 Å² buried · 11 hydrogen bonds · protein-protein
E–G · 916 Å² buried · 10 hydrogen bonds · protein-protein
F–H · 909 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 898 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

3CW2 · Crystal structure of the intact archaeal translation initiation factor 2 from Sulfolobus… · the same entry in another collection · chain N against N, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q980A5
Every structure of UniProt Q97Z79
Every structure of UniProt Q97W59
Elsewhere: RCSB PDB 3CW2 · PDBe 3CW2 · UniProt Q980A5 · UniProt Q97Z79 · UniProt Q97W59

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